Plants vs Brainrots: Mutation Machine Guide. Game Mutations Explained

Hidden fusions, unpredictable rewards, and strange plant evolutions-this guide breaks down how the Mutation Machine in Plants vs Brainrots turns simple sprouts into powerful hybrids that can change every battle.

Plants vs Brainrots Mutation Machine Rewards

The Mutation Machine in Plants vs Brainrots delivers rewards through merging mutated plants, granting coins, gems, and rare upgrades after each successful fusion. Players accumulate these bonuses by chaining merges, with higher-tier mutations yielding bigger payouts like exclusive skins or power boosts. Focus on strategic pairings to maximize daily hauls and propel your defenses against brainrot hordes.

To get rewards from the mutation merge machine in Plants vs Brainrots, you must merge two brainrots or plants with mutations. Once the merger is complete, you will get a special reward. The rewards include some top-tier Plants vs Brainrots plants, brainrots, and gears.

There are a total of 25 rewards you can get from mutation merging different plants or brainrots. Here is the list of all rewards you will receive from completing the mutation merge in the game:

Note: We will add all rewards as we complete merging more mutations.

How to Use Mutation Machine in Plants vs Brainrots

To use the Mutation Machine, first gather the required plants or brainrots that can be merged. Place two compatible characters into the machine, then activate the merge button to create a stronger or rare variant. Each merge consumes specific in-game resources, so plan combinations carefully to avoid wasting materials. Keep an eye on the reward list, as higher-tier mutations often grant special abilities or bonus stats that can boost your team’s performance in future battles.

The mutation machine works similarly to the fuse machine in Plants vs Brainrots. The mutation machine is located on the center island, which you can reach by taking the mirror at your base. Once there, walk toward the machine and hold the mutated brainrots or plants you want to merge. Press the E key to put them inside.

Also Read: All Plants vs Brainrots Eggs

After that, go near the EXP machine on the left side and use any EXP items, like a potion or a vial. This will power up the machine and start the mutation merger. If you use a frozen plant or brainrot with a neon plant or brainrot, it will make the frozenneon version of it. Remember, you must use the same type of plants or brainrots with different mutations.

The timer of mutation depends on the rarity of the brainrot. However, the mutation merging speeds up during the mutation mania weather event in Plants vs Brainrots. During this event, the mutation machine runs at a 2x speed. However, the mutation madness starts every hour and lasts for 10 minutes.

Best mutation combinations for highest damage

Best mutation combinations for highest damage in Plants vs Brainrots prioritize stacking multipliers like Neon (cash/DPS boost), Plasma (AoE damage), and Rainbow (random high-value effects), often merged into triple or quad forms for exponential output. These setups excel in Mutation Machine merges during events, turning basic plants/brainrots into late-game DPS monsters.​

Top Damage Combos

• Neon + Plasma: Neon amps base DPS by 2-5x while Plasma adds chain explosions; ideal for crowd control on waves. Merged NeonPlasma deals 10x+ normal damage.​

• Frozen + Plasma + Shock: Freezes slow enemies, Shock stuns, Plasma bursts-triple merge yields near-infinite DPS via status chaining.​

• Rainbow + Gold + Diamond: Rainbow randomizes buffs (often +damage), Gold multiplies value/DPS, Diamond pierces; quad merges hit 50x multipliers.​

Merge Priority Table

Usage Tips

Farm mutations in hourly weather cycles (e.g., Neon storms), power Machine with EXP, and merge during 2x events for fastest results. Pair with high-base DPS plants like Biohazellno for bossing. Avoid cash-focused like Gold solo-stack damage first.​

Which mutations maximize critical hit chance and damage

Mutations maximizing critical hit chance and damage in Plants vs Brainrots focus on stacking Neon for base crit multipliers, Shock for guaranteed crit procs on stunned foes, and Plasma for explosive crit scaling. These combos shine in Mutation Machine merges, amplifying DPS on high-health waves or bosses. Prioritize triple merges during events for 30-50x crit output.​

Top Crit Combos

• Neon + Shock: Neon grants 20-40% crit chance per merge level; Shock adds stun-crit synergy, hitting 60%+ chance with 2.5x damage amp.

• Plasma + Diamond + Neon: Plasma explodes on crits (base 15% chance), Diamond pierces for multi-target crits, Neon boosts to 50%+ chance and 3x damage.

• Rainbow + Shock + Frozen: Rainbow randomizes crit buffs (up to 75% chance), Shock/Frozen chain stuns for consistent procs.​

Crit Priority Table

Optimization Tips

Merge on high-DPS bases like Biohazellno seeds from rewards. Use during Mutation Mania for 2x speed and test in private servers. Avoid Gold early-focus crit stacking before cash muts.​​